Sunlenca (lenacapavir), a long-acting injectable medication recently approved for treatment-experienced people with multidrug-resistant HIV, also works well for people starting antiretroviral therapy for the first time.
Results from the CALIBRATE trial showed that around 90% of study participants who used Sunlenca—either as daily pills or injections every six months—in combination with other antiretrovirals achieved an undetectable viral load.
Gilead Sciences’ Sunlenca (formerly GS-6207), the first approved HIV capsid inhibitor, disrupts the cone-shaped shell that surrounds the viral genetic material and essential enzymes. Laboratory studies showed that it interferes with multiple steps of the HIV life cycle. Because it works differently than existing antiretrovirals, it remains active against HIV that has developed resistance to other drugs. Sunlenca has a long half-life in the body, allowing it to be administered just once every six months.
The report, published in the American Journal of Preventive Medicine (AJPM), also found “the odds of sexually transmitted infections varied by race/ethnicity, sexual orientation, and substance use.”
Research published in AIDS and Behavior show that parents in an intervention group with gay or bisexual sons can employ effective communication tactics, specifically about condoms and HIV, and other parenting behaviors to help keep their children healthy.
The study is the first to show evidence of positive effects in a randomized controlled trial with the parents of gay or bisexual sons, according to the authors. They added that these results are important because approximately 80% of all HIV infections among teens are from the gay and bisexual population. There were very few previous public health interventions seeking to lower the HIV risk among this group, according to the study.
“By focusing on the parents, this study shows we might be able to reduce HIV risk among gay and bisexual male youth,” said David Huebner, professor of Prevention and Community Health at the Milken Institute School of Public Health at the George Washington University, in a press release. “Parents represent an untapped yet promising resource in preventing HIV infection and improving sexual health among this underserved population.”
Pennsylvania’s Gov. Tom Wolf (D) just signed a new law that makes it a felony to pass on a communicable disease when they “should have known” that they had it, the HIV Justice Network reported.
Opponents of the law worry it will be used to punish people with HIV or other STDs who unknowingly transmit it to sexual partners. Such HIV criminalization laws have disproportionately been used to target Black men and other men of color.
The law, known as HB 103, punishes people with up to 7 years in prison and $15,000 in fines for “expelling” saliva, blood, or another bodily fluid onto a police officer.
“As a person living with HIV who was born and raised in Pennsylvania, the passing of HB 103 serves as a reminder that as we get closer to ending the HIV epidemic, we have a long way to go to end HIV stigma and the criminalization of people living with HIV,” said Louie Ortiz-Fonseca, Director of LGBTQ Health & Rights with Advocates for Youth.
Syphilis among newborns (i.e., congenital syphilis) also increased, with reported cases up nearly 15% from 2019, and 235% from 2016. Early data indicate primary and secondary syphilis and congenital syphilis cases continued to increase in 2021 as well.
As a result, the CDC is recommending that anyone who is sexually active get a full screening for STIs. To find local testing clinics near you, go to https://gettested.cdc.gov/. Most clinics are free.
Anthony “Tony” Silvestre, whose work with the LGBT community was far ahead of its time and made the pioneering Pitt Men’s Study possible, died Sept. 1, 2022 at 75.
Dr. Silvestre on the cover of Pittsburgh’s Out Magazine in May 1984
[…] His international advocacy and public health work began at Penn State (1971-76), continued with several Philadelphia organizations (1976-83) and brought him to Pitt in early 1984 until his retirement in 2018.
In 1976, he was the founding chairman of the Pennsylvania Governor’s Council on Sexual Minorities, likely the first such state organization in the country. He was U.S. liaison to the World Health Organization (1990-93) and a subject matter expert on HIV for the Centers for Disease Control and Prevention in 2002.
Through the years, he served on many expert and advisory panels for the Pennsylvania Department of Health and the Allegheny County Department of Health on HIV, alcohol and substance use among gender and sexual minorities, community marginalization and health education and outreach.
But he is perhaps best known in Pittsburgh for his role in forming and running the Pittsburgh AIDS Task Force (now Allies for Health and Wellbeing) in its early years. In the process, he supported more than a dozen other state and community groups promoting LGBTQIA-related and HIV-related health messaging for at-risk communities.
In conjunction with his research and teaching in the Department of Infectious Diseases and Microbiology, he founded the Pennsylvania Prevention Project (now the HIV Prevention and Care Project) there in 1993 to advance comprehensive HIV planning with impacted communities. He also helped create and direct the School of Public Health’s Center for LGBT Research, and was honored by Pitt with the Chancellor’s Distinguished Service Award.
He published more than 45 peer-reviewed articles, proceedings and book chapters, and created many state and federal professional reports and presentations as well, much of which can be found at Dickinson College.
Syphilis bottomed out in the U.S. in the late 1990s, with the CDC hoping to fully eradicate the disease. Only years later, syphilis rates would start rising; by 2021, more than 52,000 cases were reported.
Many factors could be at play, but officials believe the COVID pandemic is mostly at fault. Testing and treatment took a backseat during the worst days of the crisis in 2020, while many people now feel sexually unshackled with COVID vaccines available, lockdowns over, and mask mandates lifted. Some health officials are calling for public messaging about condoms. Monkeypox, which exploded this year and last, is also complicating efforts and eating up health funding from the government.
The CDC’s Leandro Mena, who made the announcement about STDs at a Monday speech, is calling for swift action. One of his ideas is widely available home-test kits for STDs, akin to the COVID tests common today. Mena also called for battling stigma — ostensibly through public relations, marketing, or public service announcements — and increased testing and treatment.
[…] An analysis of national 2017 data found that 45% of people living with HIV report some form of disability—and that mobility disabilities were the most common. Fully one in four people reported them. And that’s among all adults living with HIV. At middle age, men with HIV walked more slowly, and continued to decline faster, than their HIV-negative peers.
By their 50s, Black men living with HIV were nearly three times likelier than white folks with the virus to have a mobility disability. These racial disparities were seen only in people living with HIV, not among the HIV-negative population. And the proportion of people with mobility disabilities rose significantly as people reached 65 or older. For women living with HIV, mobility was lower than it was for men with the virus.
Slow walking, limited movement and difficulty standing from a sitting position are three of the criteria required for a diagnosis of frailty, a condition of aging that can make it harder for people to recover from episodic illnesses. The good news is that mobility aids can keep people moving, which is associated with better overall health as one ages.
[…] The proportion of older people living with HIV has been increasing, and 55% of people included in this survey were over age 50. People ages 40 to 49 accounted for 19% of respondents, those ages 30 to 39 for 18% and those ages 18 to 29 for 8%.
This report confirms that HIV disproportionately affects Black and Latino Americans, underlining the importance of targeted care and outreach for these groups. In this analysis, 42% of people with diagnosed HIV were Black, 29% were white, 24% were Latino and 6% were another race or ethnicity. When accounting for their share of the total population, Black Americans are 3.4 times more likely, and Latinos are 1.3 times more likely, to be diagnosed with HIV.
People with diagnosed HIV were more likely than the population at large to face socioeconomic challenges that can make it more difficult to maintain good health, including poverty, unemployment and homelessness.
If you or someone you love has been affected by HIV, the PA Department of Health and the HIV Prevention and Care Project at the University of Pittsburgh need your input.
This plan guides all activities related to HIV prevention and care in Pennsylvania. Feedback will help the Division of HIV Disease most effectively plan for the ongoing needs of all people served in Pennsylvania.
